In this game; each player fields one of the superhero teams; with each hero — Captain America; Wolverine; Spider-Man; and more — being represented by custom-tooled dice; each team must be composed of up to 20 dice; and a player can purchase dice only from his team. Each hero also has one or more character reference cards; which show the special abilities for the characters based on the die rolls. Different versions of these cards will be available in booster packs; allowing for more customization of your team. Players use these dice to collect energy; recruit new heroes; and battle head-to-head. In addition; each player brings two basic action cards to the game; which are placed in the center of the table; both players can purchase these cards. A player wins once the opposing player has been reduced to zero life.

The Marvel Dice Masters: Avengers vs. X-Men starter set comes with 44 custom dice; 38 cards; two dice bags; and a core rulebook. Booster packs include two dice with two matching character cards.